Article
A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation.
Nature medicine - 1 Mar 1998
Kostrikis L G, Huang Y, Moore J P, Wolinsky S M, Zhang L, Guo Y, Deutsch L, Phair J, Neumann A U, Ho D D
Abstract excerpt
Viral and host factors influence the rate of HIV-1 disease progression. For HIV-1 to fuse, a CD4+ cell must express a co-receptor that the virus can use. The chemokine receptors CCR5 and CXCR4 are used by R5 and X4 viruses, respectively. Most new infections involve transmission of R5 viruses, but...
Topics
- Alleles
- CD4 Lymphocyte Count
- Cohort Studies
- Disease Progression
- Genotype
- HIV Infections
- HIV Seropositivity
- HIV Seroprevalence
- HIV-1
- Heterozygote
- Homozygote
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Prognosis