Article
A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation.
Nature medicine - 1 Mar 1998
Kostrikis L G, Huang Y, Moore J P, Wolinsky S M, Zhang L, Guo Y, Deutsch L, Phair J, Neumann A U, Ho D D
Abstract excerpt
Viral and host factors influence the rate of HIV-1 disease progression. For HIV-1 to fuse, a CD4+ cell must express a co-receptor that the virus can use. The chemokine receptors CCR5 and CXCR4 are used by R5 and X4 viruses, respectively. Most new infections involve transmission of R5 viruses, but variants can arise later that also use CXCR4 (R5-X4 or X4 viruses). This is associated with an increased rate of CD4+...
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