Article
Human chromosome 21 determines growth factor dependence in human/mouse B-cell hybridomas.
Cancer research - 1 Jul 1998
Ebeling S B, Bos H M, Slater R, Overkamp W J, Cuthbert A P, Newbold R F, Zdzienicka M Z, Aarden L A
Abstract excerpt
Interleukin 6 (IL-6) serves as a growth factor for mouse plasmacytomas. As a model for IL-6-mediated growth of plasmacytomas, we study IL-6-dependent B-cell hybridomas, which can be generated through fusion of B lymphocytes with a plasmacytoma cell line, e.g., SP2/0. In the present report, we have investigated the peculiar behavior of B-cell hybridomas with respect to IL-6 dependence. We demonstrate that although...
Topics
- Animals
- B-Lymphocytes
- Cell Division
- Chromosomes, Human, Pair 21
- Female
- Humans
- Hybridomas
- Interleukin-6
- Karyotyping
- Mice
- Phenotype