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Article

Human chromosome 21 determines growth factor dependence in human/mouse B-cell hybridomas.

Cancer research - 1 Jul 1998

Ebeling S B, Bos H M, Slater R, Overkamp W J, Cuthbert A P, Newbold R F, Zdzienicka M Z, Aarden L A

Abstract excerpt

Interleukin 6 (IL-6) serves as a growth factor for mouse plasmacytomas. As a model for IL-6-mediated growth of plasmacytomas, we study IL-6-dependent B-cell hybridomas, which can be generated through fusion of B lymphocytes with a plasmacytoma cell line, e.g., SP2/0. In the present report, we have investigated the peculiar behavior of B-cell hybridomas with respect to IL-6 dependence. We demonstrate that although...

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PMID: 9661903

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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