Functionally distinct human marrow stromal cell lines immortalized by transduction with the human papilloma virus E6/E7 genes.

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Article

Functionally distinct human marrow stromal cell lines immortalized by transduction with the human papilloma virus E6/E7 genes.

Blood - 15 Feb 1995

Roecklein B A, Torok-Storb B

Abstract excerpt

A replication-defective recombinant retrovirus containing the human papilloma virus E6/E7 genes (LXSN-16 E6E7) was used to immortalize stromal cells from human marrow. The E6/E7 gene products interfere with the function of tumor-suppressor proteins p53 and Rb, respectively, thereby preventing cel...

Topics

Adipocytes
Adult
Alkaline Phosphatase
Antigens, CD
Blotting, Southern
Bone Marrow Cells
Cell Differentiation
Cell Line, Transformed
DNA
DNA, Viral
Dexamethasone
Fluorescent Antibody Technique

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Viral

Humans

Hydrocortisone

Insulin

Oncogene Proteins, Viral

Papillomaviridae

Source

Open in PubMed

Identifiers

PMID: 7849321

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7849321-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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