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Article

Role of interleukin 6 in the growth of myeloma-derived cell lines.

Leukemia research - 1 Oct 1992

Barut B A, Zon L I, Cochran M K, Paul S R, Chauhan D, Mohrbacher A, Fingeroth J, Anderson K C

Abstract excerpt

The role of interleukin 6 (IL-6) in the growth of five multiple myeloma-derived cell lines was characterized. The U266 and RPMI 8226 cell lines demonstrated increased DNA synthesis when cultured with exogenous IL-6, expressed IL-6 cell surface receptors (IL-6Rs) and expressed mRNA for IL-6R. However, these cells did not secrete detectable IL-6 protein, and a neutralizing antibody to IL-6 did not inhibit their...

Topics

Blotting, Northern
Blotting, Western
DNA
Humans
Interleukin-6
Multiple Myeloma
Phenotype
Polymerase Chain Reaction
Receptors, Immunologic
Receptors, Interleukin-6
Tumor Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1405708
DOI: 10.1016/0145-2126(92)90073-g

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1405708-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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