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Article

IL-6 and MYC collaborate in plasma cell tumor formation in mice

18 Dec 2009

Abstract excerpt

Interleukin-6 (IL-6) plays a critical role in the natural history of human plasma cell neoplasms (PCNs), such as plasma cell myeloma and plasmacytoma (PCT). IL-6 is also at the center of neoplastic plasma cell transformation in BALB/c (C) mice carrying a transgene, H2-L(d)-IL6, that encodes human IL-6 under control of the major histocompatibility complex H2-L(d) promoter: strain C.H2-L(d)-IL6. These mice are...

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PMID: 20018915
DOI: 10.1182/blood-2009-08-237941

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