Article
Differentiation of HL-60 cells into cells with the osteoclast phenotype.
Endocrinology - 1 Aug 1991
Yoneda T, Alsina M M, Garcia J L, Mundy G R
Abstract excerpt
The osteoclast is the unique multinucleated cell that is responsible for bone degradation in both physiological and pathological circumstances. However, knowledge of the lineage of this inaccessible cell, the nature of its precursors, and the regulation of its formation and activation is limited and controversial. Here we show that the human promyelocytic cell line HL-60 has the potential, under the appropriate...
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