Differentiation of HL-60 cells into cells with the osteoclast phenotype.

doi:10.1210/endo-129-2-683

Back to search

Article

Differentiation of HL-60 cells into cells with the osteoclast phenotype.

Endocrinology - 1 Aug 1991

Yoneda T, Alsina M M, Garcia J L, Mundy G R

Abstract excerpt

The osteoclast is the unique multinucleated cell that is responsible for bone degradation in both physiological and pathological circumstances. However, knowledge of the lineage of this inaccessible cell, the nature of its precursors, and the regulation of its formation and activation is limited...

Topics

Bone Resorption
Calcitonin
Calcitriol
Carcinoma, Squamous Cell
Cell Differentiation
Cell Nucleus
Hematopoietic Stem Cells
Humans
Immunoenzyme Techniques
Leukemia, Promyelocytic, Acute
Osteoclasts
Phenotype
Receptors, Calcitonin
Receptors, Cell Surface
Tumor Cells, Cultured

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.