Article
Establishment and characterization of an immortal macrophage-like cell line inducible to differentiate to osteoclasts.
Biochemical and biophysical research communications - 26 Jan 1998
Miyamoto A, Kunisada T, Hemmi H, Yamane T, Yasuda H, Miyake K, Yamazaki H, Hayashi S I
Abstract excerpt
Osteoclasts are hematopoietic cells essential for bone remodeling and resorption. To understand the process of osteoclast development, we established a macrophage-like cell line C7 that has the potential to differentiate into functional osteoclasts; multinuclear tartrate-resistant acid phosphatase positive cells capable of forming pits on dentin slices. C7 cells share the characteristics of their cell surface...
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