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Article

Characterization of immortalized osteoclast precursors developed from mice transgenic for both bcl-X(L) and simian virus 40 large T antigen.

Endocrinology - 1 Jul 1999

Hentunen T A, Jackson S H, Chung H, Reddy S V, Lorenzo J, Choi S J, Roodman G D

Abstract excerpt

We recently developed an immortalized osteoclast (OCL) precursor cell line that forms large numbers of OCLs. This cell line was derived from mice doubly transgenic for bcl-X(L) and large T antigen that was targeted to cells in the OCL lineage (bcl-X(L)/Tag cells). We have now characterized these cells in terms of their surface and enzymatic phenotype, responsiveness to osteotropic factors, and differentiation...

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Source

Identifiers

PMID: 10385386
DOI: 10.1210/endo.140.7.6867

Genes

PTH
MMP9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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