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Article

Absence of Gcn5 HAT activity defines a novel state in the opening of chromatin at the PHO5 promoter in yeast.

Molecular cell - 1 Mar 1998

Gregory P D, Schmid A, Zavari M, Lui L, Berger S L, Hörz W

Abstract excerpt

Histone acetyltransferase (HAT) activity has been demonstrated for several transcriptional activators, formally connecting chromatin modification with gene regulation. However, no effect on chromatin has been demonstrated. We have investigated the role of the HAT Gcn5 at the nucleosomally regulated PHO5 promoter. Under conditions of constitutive submaximal activation (i.e., in the absence of the negative...

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PMID: 9660934
DOI: 10.1016/s1097-2765(00)80050-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Absence of Gcn5 HAT activity defines a novel state in the opening of chromatin at the PHO5 promoter in yeast.PMID 9660934Read ↗

Redundancy of chromatin remodeling pathways for the induction of the yeast PHO5 promoter in vivo.Semantic proximity Read ↗

Occlusion of regulatory sequences by promoter nucleosomes in vivo.Semantic proximity Read ↗

Role of trans-activating proteins in the generation of active chromatin at the PHO5 promoter in S. cerevisiae.Semantic proximity Read ↗

Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo.Semantic proximity Read ↗

Single-cell nucleosome mapping reveals the molecular basis of gene expression heterogeneity.Semantic proximity Read ↗

Recruitment of the NuA4 complex poises the PHO5 promoter for chromatin remodeling and activation.Semantic proximity Read ↗

Nucleosomal promoter variation generates gene expression noise.Semantic proximity Read ↗

Topoisomerase II regulates yeast genes with singular chromatin architectures.Semantic proximity Read ↗

Cell cycle-specified fluctuation of nucleosome occupancy at gene promoters.Semantic proximity Read ↗

Regulation of PHO4 nuclear localization by the PHO80-PHO85 cyclin-CDK complex.Semantic proximity Read ↗

Quantitative analysis of the transcription control mechanism.Semantic proximity Read ↗

Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription.Semantic proximity Read ↗

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