Article
Recruitment of the NuA4 complex poises the PHO5 promoter for chromatin remodeling and activation.
The EMBO journal - 7 Jul 2004
Nourani Amine, Utley Rhea T, Allard Stéphane, Côté Jacques
Abstract excerpt
The remodeling of the promoter chromatin structure is a key event for the induction of the PHO5 gene. Two DNA-binding proteins Pho2 and Pho4 are critical for this step. We found that the NuA4 histone acetyltransferase complex is essential for PHO5 transcriptional induction without affecting Pho4 translocation upon phosphate starvation. Our data also indicate that NuA4 is critical for the chromatin remodeling...
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