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Article

Regulation of PHO4 nuclear localization by the PHO80-PHO85 cyclin-CDK complex.

Science (New York, N.Y.) - 12 Jan 1996

O'Neill E M, Kaffman A, Jolly E R, O'Shea E K

Abstract excerpt

PHO4, a transcription factor required for induction of the PHO5 gene in response to phosphate starvation, is phosphorylated by the PHO80-PHO85 cyclin-CDK (cyclin-dependent kinase) complex when yeast are grown in phosphate-rich medium. PHO4 was shown to be concentrated in the nucleus when yeast were starved for phosphate and was predominantly cytoplasmic when yeast were grown in phosphate-rich medium. The sites of...

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Identifiers

PMID: 8539622
DOI: 10.1126/science.271.5246.209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of PHO4 nuclear localization by the PHO80-PHO85 cyclin-CDK complex.PMID 8539622Read ↗

Regulation of the Pcl7-Pho85 cyclin-cdk complex by Pho81.Semantic proximity Read ↗

A systematic high-throughput screen of a yeast deletion collection for mutants defective in PHO5 regulation.Semantic proximity Read ↗

Multi-site phosphorylation of Pho4 by the cyclin-CDK Pho80-Pho85 is semi-processive with site preference.Semantic proximity Read ↗

Disruption of histone deacetylase gene RPD3 accelerates PHO5 activation kinetics through inappropriate Pho84p recycling.Semantic proximity Read ↗

The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus.Semantic proximity Read ↗

New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis.Semantic proximity Read ↗

Yeast Pho85 kinase is required for proper gene expression during the diauxic shift.Semantic proximity Read ↗

Functional domains of a positive regulatory protein, PHO4, for transcriptional control of the phosphatase regulon in Saccharomyces cerevisiae.Semantic proximity Read ↗

OsCYCP1;1, a PHO80 homologous protein, negatively regulates phosphate starvation signaling in the roots of rice (Oryza sativa L.).Semantic proximity Read ↗

Chemical inhibition of the Pho85 cyclin-dependent kinase reveals a role in the environmental stress response.Semantic proximity Read ↗

Coupling phosphate homeostasis to cell cycle-specific transcription: mitotic activation of Saccharomyces cerevisiae PHO5 by Mcm1 and Forkhead proteins.Semantic proximity Read ↗

Intracellular phosphate serves as a signal for the regulation of the PHO pathway in Saccharomyces cerevisiae.Semantic proximity Read ↗

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