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Article

Nucleosomal promoter variation generates gene expression noise.

Proceedings of the National Academy of Sciences of the United States of America - 16 Dec 2014

Brown Christopher R, Boeger Hinrich

Abstract excerpt

Gene product molecule numbers fluctuate over time and between cells, confounding deterministic expectations. The molecular origins of this noise of gene expression remain unknown. Recent EM analysis of single PHO5 gene molecules of yeast indicated that promoter molecules stochastically assume alternative nucleosome configurations at steady state, including the fully nucleosomal and nucleosome-free configuration....

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Identifiers

PMID: 25468975
DOI: 10.1073/pnas.1417527111
PMCID: PMC4273403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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