Article
Single-cell nucleosome mapping reveals the molecular basis of gene expression heterogeneity.
Proceedings of the National Academy of Sciences of the United States of America - 17 Jun 2014
Small Eliza C, Xi Liqun, Wang Ji-Ping, Widom Jonathan, Licht Jonathan D
Abstract excerpt
Nucleosomes, the basic unit of chromatin, have a critical role in the control of gene expression. Nucleosome positions have generally been determined by examining bulk populations of cells and then correlated with overall gene expression. Here, we describe a technique to determine nucleosome positioning in single cells by virtue of the ability of the nucleosome to protect DNA from GpC methylation. In the acid...
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