Article
Molecular mechanisms of serum resistance of human influenza H3N2 virus and their involvement in virus adaptation in a new host.
Journal of virology - 1 Aug 1998
Matrosovich M, Gao P, Kawaoka Y
Abstract excerpt
H3N2 human influenza viruses that are resistant to horse, pig, or rabbit serum possess unique amino acid mutations in their hemagglutinin (HA) protein. To determine the molecular mechanisms of this resistance, we characterized the receptor-binding properties of these mutants by measuring their af...
Topics
- Acetylation
- Adaptation, Physiological
- Animals
- Antiviral Agents
- Chick Embryo
- Drug Resistance, Microbial
- Galactose
- Glycoproteins
- Horses
- Humans
- Influenza A Virus, H3N2 Subtype
- Influenza A virus
- Lectins
- Mannose
- N-Acetylneuraminic Acid
- Phenotype
- Rabbits
- Receptors, Virus