Article
Complex N-glycans are important for interspecies transmission of H7 influenza A viruses.
Journal of virology - 16 Apr 2024
Spruit Cindy M, Palme Diana I, Li Tiehai, Ríos Carrasco María, Gabarroca García Alba, Sweet Igor R, Kuryshko Maryna, Maliepaard Joshua C L, Reiding Karli R, Scheibner David, Boons Geert-Jan, Abdelwhab Elsayed M, de Vries Robert P
Abstract excerpt
Influenza A viruses (IAVs) can overcome species barriers by adaptation of the receptor-binding site of the hemagglutinin (HA). To initiate infection, HAs bind to glycan receptors with terminal sialic acids, which are either N-acetylneuraminic acid (NeuAc) or N-glycolylneuraminic acid (NeuGc); the latter is mainly found in horses and pigs but not in birds and humans. We investigated the influence of previously...
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