Article
[The effect of losing glycosylation sites near the receptor-binding region on the receptor phenotype of the human influenza virus H1N1].
Molekuliarnaia biologiia - 1 Jan 2000
Marinina V P, Gambarian A S, Bovin N V, Tuzikov A B, Shilov A A, Sinitsyn B V, Matrosovich M N
Abstract excerpt
The receptor properties of influenza virus (IF) isolates/SSSR/90/77 are studied. The isolates are peculiar for losing glycosylation sites (GS) at the Asn131 receptor-binding region (GS131) after passaging in mice and at the Asn158 region (GS158) after cultivation in the presence of mouse serum. The loss of each carbohydrate residue increases the influenza virus affinity for carbohydrate chains with the terminal...
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