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Article

Mutation W222L at the Receptor Binding Site of Hemagglutinin Could Facilitate Viral Adaption from Equine Influenza A(H3N8) Virus to Dogs.

Journal of virology - 15 Sept 2018

Wen Feng, Blackmon Sherry, Olivier Alicia K, Li Lei, Guan Minhui, Sun Hailiang, Wang Peng George, Wan Xiu-Feng

Abstract excerpt

An outbreak of respiratory disease caused by the equine-origin influenza A(H3N8) virus was first detected in dogs in 2004 and since then has been enzootic among dogs. Currently, the molecular mechanisms underlying host adaption of this virus from horses to dogs is unknown. Here, we have applied quantitative binding, growth kinetics, and immunofluorescence analyses to elucidate these mechanisms. Our findings...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29997206
DOI: 10.1128/JVI.01115-18
PMCID: PMC6146684

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