Article
A deletion in the Friend spleen focus-forming virus env gene is necessary for its product (gp55) to be leukemogenic.
Journal of virology - 1 Jun 1990
Watanabe N, Nishi M, Ikawa Y, Amanuma H
Abstract excerpt
To determine the biological significance of the 585-base-pair deletion in the env gene of Friend spleen focus-forming virus (SFFV) encoding a leukemogenic glycoprotein (gp55), we examined the pathogenicity of a constructed mutant SFFV (SFFVDF). In the SFFVDF genome, the env deletion was filled in...
Topics
- Animals
- Base Sequence
- Cells, Cultured
- Chromosome Deletion
- DNA, Viral
- Gene Products, rev
- Genes, Viral
- Genes, rev
- Genetic Variation
- Leukemia Virus, Murine
- Leukemia, Experimental
- Mice
- Mice, Inbred DBA
- Molecular Sequence Data
- Molecular Weight
- Mutation
- Oligonucleotide Probes
- Plasmids