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Article

A deletion in the Friend spleen focus-forming virus env gene is necessary for its product (gp55) to be leukemogenic.

Journal of virology - 1 Jun 1990

Watanabe N, Nishi M, Ikawa Y, Amanuma H

Abstract excerpt

To determine the biological significance of the 585-base-pair deletion in the env gene of Friend spleen focus-forming virus (SFFV) encoding a leukemogenic glycoprotein (gp55), we examined the pathogenicity of a constructed mutant SFFV (SFFVDF). In the SFFVDF genome, the env deletion was filled in with the corresponding env sequence of Friend mink cell focus-forming virus, whereas the 6-base-pair duplication and...

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Identifiers

PMID: 2159537
DOI: 10.1128/JVI.64.6.2678-2686.1990
PMCID: PMC249446

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Source receipt: pubmed, retrieved 7 Sept 2026.

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A deletion in the Friend spleen focus-forming virus env gene is necessary for its product (gp55) to be leukemogenic.PMID 2159537Read ↗

Pathogenicity of a mutant friend spleen focus-forming virus encoding an Env-like membrane glycoprotein (gp55) with substitution by a xenotropic murine leukemia virus Env gp70 sequence.Semantic proximity Read ↗

A 585-bp deletion found in the spleen focus-forming virus (SFFV) env gene is responsible for the defective intracellular transport of SFFV gp52.Semantic proximity Read ↗

A carboxy-terminal mutant spleen focus-forming virus (SFFV) envelope glycoprotein is transport-competent, but non-leukemogenic.Semantic proximity Read ↗

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Mutations in the env gene of friend spleen focus-forming virus overcome Fv-2r-mediated resistance to Friend virus-induced erythroleukemia.Semantic proximity Read ↗

A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia.Semantic proximity Read ↗

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Fusion of the erythropoietin receptor and the Friend spleen focus-forming virus gp55 glycoprotein transforms a factor-dependent hematopoietic cell line.Semantic proximity Read ↗

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