Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Leukemogenesis Caused by Incapacitated GATA-1 Function

30 Nov 2004

Abstract excerpt

GATA-1 is essential for the development of erythroid and megakaryocytic lineages. We found that GATA-1 gene knockdown female (GATA-1.05/X) mice frequently develop a hematopoietic disorder resembling myelodysplastic syndrome that is characterized by the accumulation of progenitors expressing low levels of GATA-1. In this study, we demonstrate that GATA-1.05/X mice suffer from two distinct types of acute leukemia,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Epigenetics and DNA Methylation
Share to Genomics and Chromatin Dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15572684
DOI: 10.1128/mcb.24.24.10814-10825.2004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Leukemogenesis Caused by Incapacitated GATA-1 FunctionPMID 15572684Read ↗

Role of GATA-1 in proliferation and differentiation of definitive erythroid and megakaryocytic cells in vivo.Semantic proximity Read ↗

Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignanciesSemantic proximity Read ↗

GATA-related hematologic disorders.Semantic proximity Read ↗

Arrest in primitive erythroid cell development caused by promoter-specific disruption of the GATA-1 gene.Semantic proximity Read ↗

Hematological phenotypes in GATA2 deficiency syndrome arise from aging, maladaptation to proliferation, and somatic eventsSemantic proximity Read ↗

Hematological phenotypes in GATA2 deficiency syndrome arise from secondary injuries and maladaptation to proliferationSemantic proximity Read ↗

Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1.Semantic proximity Read ↗

Early block to erythromegakaryocytic development conferred by loss of transcription factor GATA-1.Semantic proximity Read ↗

Gata1 expression driven by the alternative HS2 enhancer in the spleen rescues the hematopoietic failure induced by the hypomorphic Gata1low mutation.Semantic proximity Read ↗

Targeted Deletion of a High-Affinity GATA-binding Site in the GATA-1 Promoter Leads to Selective Loss of the Eosinophil Lineage In VivoSemantic proximity Read ↗

GATA transcription factors in hematologic disease.Semantic proximity Read ↗

GATA1 in normal and malignant hematopoiesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.