Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of tumor necrosis factor gene polymorphisms on patients with congestive heart failure. VEST Investigators for TNF Genotype Analysis. Vesnarinone Survival Trial.

Circulation - 30 Jun 1998

Kubota T, McNamara D M, Wang J J, Trost M, McTiernan C F, Mann D L, Feldman A M

Abstract excerpt

BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) is known to be elevated in patients with congestive heart failure (CHF). Two biallelic polymorphisms have been identified in the TNF gene locus: one in the promoter region of TNF-alpha (TNFA1/2), and the other in the first intron of TNF-beta (TNFB1/2). Both TNFA2 and TNFB2 alleles are associated with high TNF-alpha production in vitro and susceptibility to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Disease Susceptibility

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Primers

Share to TNF gene

Share to Genotype

Share to Polymorphism, Genetic

Share to Severity of Illness Index

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 9657468
DOI: 10.1161/01.cir.97.25.2499

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of tumor necrosis factor gene polymorphisms on patients with congestive heart failure. VEST Investigators for TNF Genotype Analysis. Vesnarinone Survival Trial.PMID 9657468Read ↗

The methionine 196 arginine polymorphism of the TNF receptor 2 gene (TNFRSF1B) is not associated with worse outcomes in heart failure.Semantic proximity Read ↗

Tumor necrosis factor gene polymorphism is associated with enhanced systemic inflammatory response and increased cardiopulmonary morbidity after cardiac surgery.Semantic proximity Read ↗

Association between the TNF-2 allele and a better survival in cardiogenic shock.Semantic proximity Read ↗

Tumor necrosis factor alpha polymorphism in heart failure/cardiomyopathy.Semantic proximity Read ↗

Tumor necrosis factor gene polymorphisms and inflammatory response in coronary artery bypass grafting patients.Semantic proximity Read ↗

Variants of trophic factors and expression of cardiac hypertrophy in patients with hypertrophic cardiomyopathy.Semantic proximity Read ↗

TNF-alpha gene promoter polymorphism at nucleotide -308 and the inflammatory response and oxidative stress induced by cardiac surgery: role of heart failure and medical treatment.Semantic proximity Read ↗

[Carriage of A Allele of Polymorphic Marker G(-238)A of TNF Gene Is Associated With Unfavorable Prognosis in Patients With Chronic Systolic Heart Failure].Semantic proximity Read ↗

Tumor necrosis factor alpha influences the inflammatory response after coronary surgery.Semantic proximity Read ↗

TNFalpha in patients with end-stage heart failure on medical therapy or supported by a left ventricular assist device.Semantic proximity Read ↗

Tumour necrosis factor alpha gene polymorphism: a predisposing factor to non-ischaemic myocardial dysfunction?Semantic proximity Read ↗

Differences in biochemical and genetic biomarkers in patients with heart failure of various etiologies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.