Article
Effects of tumor necrosis factor gene polymorphisms on patients with congestive heart failure. VEST Investigators for TNF Genotype Analysis. Vesnarinone Survival Trial.
Circulation - 30 Jun 1998
Kubota T, McNamara D M, Wang J J, Trost M, McTiernan C F, Mann D L, Feldman A M
Abstract excerpt
BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) is known to be elevated in patients with congestive heart failure (CHF). Two biallelic polymorphisms have been identified in the TNF gene locus: one in the promoter region of TNF-alpha (TNFA1/2), and the other in the first intron of TNF-beta (TN...
Topics
- Adult
- Case-Control Studies
- DNA Primers
- Disease Susceptibility
- Female
- Genotype
- Heart Failure
- Humans
- Lymphotoxin-alpha
- Male
- Middle Aged
- Polymorphism, Genetic
- Severity of Illness Index
- Tumor Necrosis Factor-alpha