The methionine 196 arginine polymorphism of the TNF receptor 2 gene (TNFRSF1B) is not associated with worse outcomes in heart failure.

doi:10.1016/j.cyto.2012.07.035

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Article

The methionine 196 arginine polymorphism of the TNF receptor 2 gene (TNFRSF1B) is not associated with worse outcomes in heart failure.

Cytokine - 1 Dec 2012

McTiernan Charles F, Ramani Ravi, Burkhead Benjamin, McNamara Dennis

Abstract excerpt

Tumor necrosis factor α (TNFα) may contribute to the pathologic process of congestive heart failure (CHF). TNFα signaling occurs through two receptors; TNFR1 (TNFRSF1A) and TNFRII (TNFRSF1B). In humans a single nucleotide polymorphism (rs1061622 in TNFRSF1B exon 6; T587G) encodes two different amino acids (M196R) in the transmembrane region. The 587G allele is associated with greater severity and/or prevalence of...

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PMID: 22921902
DOI: 10.1016/j.cyto.2012.07.035
PMCID: PMC3592567

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