Lack of association between human longevity and genetic polymorphisms in drug-metabolizing enzymes at the NAT2, GSTM1 and CYP2D6 loci.

doi:10.1007/s004390050735

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Article

Lack of association between human longevity and genetic polymorphisms in drug-metabolizing enzymes at the NAT2, GSTM1 and CYP2D6 loci.

Human genetics - 1 May 1998

Muiras M L, Verasdonck P, Cottet F, Schächter F

Abstract excerpt

In the present study, the possible role of genetic polymorphism of three drug-metabolizing enzymes, debrisoquine/sparteine hydroxylase (CYP2D6), glutathione S-transferase mu (GSTM1), and N-acetyltransferase (NAT2), as a putative genetic component of human longevity, was explored. A total of 817 D...

Topics

Adult
Aged
Aged, 80 and over
Arylamine N-Acetyltransferase
Cytochrome P-450 CYP2D6
Female
Gene Deletion
Glutathione Transferase
Humans
Longevity
Male
Middle Aged
Mutation
Polymorphism, Genetic
Xenobiotics

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