Article
Debrisoquin and S-mephenytoin hydroxylation phenotypes and CYP2D6 genotypes in an Estonian population.
Pharmacology & toxicology - 1 May 1996
Marandi T, Dahl M L, Kiivet R A, Rägo L, Sjöqvist F
Abstract excerpt
The polymorphisms of debrisoquin (CYP2D6) and S-mephenytoin (CYP2C19) hydroxylation were studied in 210 unrelated healthy native Estonians by coadministration of mephenytoin and debrisoquin or dextromethorphan. Among the 210 volunteers 21 (10%) were poor metabolizers of debrisoquin/dextromethorph...
Topics
- Adolescent
- Adult
- Anticonvulsants
- Aryl Hydrocarbon Hydroxylases
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Estonia
- Female
- Genotype
- Humans
- Hydroxylation
- Male
- Mephenytoin
- Middle Aged
- Mixed Function Oxygenases
- Phenotype