Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of p63 transcriptional activity by p14ARF: functional and physical link between human ARF tumor suppressor and a member of the p53 family.

Molecular and cellular biology - 1 Oct 2004

Calabrò Viola, Mansueto Gelsomina, Santoro Raffaela, Gentilella Antonio, Pollice Alessandra, Ghioni Pamela, Guerrini Luisa, La Mantia Girolama

Abstract excerpt

The ARF/MDM2/p53 pathway is a principal defense mechanism to protect the organism from uncontrolled effects of deregulated oncogenes. Oncogenes activate ARF, which interacts with and inhibits the ubiquitin ligase MDM2, resulting in p53 stabilization and activation. Once stabilized and activated,...

Topics

Animals
COS Cells
Chlorocebus aethiops
Gene Expression Regulation
Mice
Mutation
NIH 3T3 Cells
Phosphoproteins
Promoter Regions, Genetic
Trans-Activators
Tumor Suppressor Protein p14ARF

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 15367673
DOI: 10.1128/MCB.24.19.8529-8540.2004
PMCID: PMC516740

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-15367673-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of p63 transcriptional activity by p14ARF: functional and physical link between human ARF tumor suppressor and a member of the p53 family.PMID 15367673Read ↗

Post-Translational Regulation of ARF: Perspective in CancerSemantic proximity Read ↗

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2Semantic proximity Read ↗

Downregulation of ΔNp63α in keratinocytes by p14ARF-mediated SUMO-conjugation and degradationSemantic proximity Read ↗

Association of p14ARF with the p120E4FTranscriptional Repressor Enhances Cell Cycle InhibitionSemantic proximity Read ↗

It’s Getting Complicated—A Fresh Look at p53-MDM2-ARF Triangle in Tumorigenesis and Cancer TherapySemantic proximity Read ↗

Dynamics of ARF regulation that control senescence and cancerSemantic proximity Read ↗

DNA Damage Disrupts the p14ARF-B23(Nucleophosmin) Interaction and Triggers a Transient Subnuclear Redistribution of p14ARFSemantic proximity Read ↗

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.Semantic proximity Read ↗

The ARF tumor suppressor: Structure, functions and status in cancerSemantic proximity Read ↗

A Novel Nuclear Interactor of ARF and MDM2 (NIAM) That Maintains Chromosomal StabilitySemantic proximity Read ↗

The Human ARF Cell Cycle Regulatory Gene Promoter Is a CpG Island Which Can Be Silenced by DNA Methylation and Down-Regulated by Wild-Type p53Semantic proximity Read ↗

Non-Canonical Functions of the ARF Tumor Suppressor in Development and TumorigenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.