Article
Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.
Molecular and cellular biology - 1 Apr 2000
Weber J D, Kuo M L, Bothner B, DiGiammarino E L, Kriwacki R W, Roussel M F, Sherr C J
Abstract excerpt
The ARF tumor suppressor protein stabilizes p53 by antagonizing its negative regulator, Mdm2 (Hdm2 in humans). Both mouse p19(ARF) and human p14(ARF) bind to the central region of Mdm2 (residues 210 to 304), a segment that does not overlap with its N-terminal p53-binding domain, nuclear import or export signals, or C-terminal RING domain required for Mdm2 E3 ubiquitin ligase activity. The N-terminal 37 amino...
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