Article
Targeted disruption of the interferon-gamma receptor 2 gene results in severe immune defects in mice.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jul 1998
Lu B, Ebensperger C, Dembic Z, Wang Y, Kvatyuk M, Lu T, Coffman R L, Pestka S, Rothman P B
Abstract excerpt
To study the role of the interferon- (IFN) gammaR2 chain in IFN-gamma signaling and immune function, IFN-gammaR2-deficient mice have been generated and characterized. Cells derived from IFN-gammaR2 -/- mice are unable to activate either JAK/STAT signaling proteins or gene transcription in respons...
Topics
- Animals
- Disease Susceptibility
- Gene Deletion
- Genetic Predisposition to Disease
- Immune System Diseases
- Interferon-gamma
- Listeriosis
- Mice
- Mice, Knockout
- Receptors, Interferon
- Signal Transduction
- Interferon gamma Receptor