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Article

Targeted disruption of the interferon-gamma receptor 2 gene results in severe immune defects in mice.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jul 1998

Lu B, Ebensperger C, Dembic Z, Wang Y, Kvatyuk M, Lu T, Coffman R L, Pestka S, Rothman P B

Abstract excerpt

To study the role of the interferon- (IFN) gammaR2 chain in IFN-gamma signaling and immune function, IFN-gammaR2-deficient mice have been generated and characterized. Cells derived from IFN-gammaR2 -/- mice are unable to activate either JAK/STAT signaling proteins or gene transcription in response to IFN-gamma. The lack of IFN-gamma responsiveness alters IFN-gamma-induced Ig class switching by B cells from these...

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Identifiers

PMID: 9653170
DOI: 10.1073/pnas.95.14.8233
PMCID: PMC20959

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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