Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Type I interferons and autoimmunity: lessons from the clinic and from IRF-2-deficient mice.

Cytokine & growth factor reviews - 1 Jan 2000

Taki Shinsuke

Abstract excerpt

Type I interferons (IFN-alpha/beta) are produced upon viral and bacterial infections and play essential roles in host defense. However, since IFN-alpha/beta have multiple regulatory functions on innate and adoptive immunity, dysregulation of the IFN-alpha/beta system both in uninfected hosts and during immune responses against infection can result in immunopathologies. In fact, IFN-alpha/beta therapy often...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immunologic Deficiency Syndromes
Share to Immunologic Factors
Share to Interferon-beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Immunological

Share to Multiple Sclerosis

Share to Receptors, Interferon

Share to Skin Diseases

Share to T-Lymphocyte Subsets

Source

Identifiers

PMID: 12220551
DOI: 10.1016/s1359-6101(02)00023-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Type I interferons and autoimmunity: lessons from the clinic and from IRF-2-deficient mice.PMID 12220551Read ↗

TYPE I INTERFERONS (α/β) IN IMMUNITY AND AUTOIMMUNITYSemantic proximity Read ↗

Does type-I interferon drive systemic autoimmunity?Semantic proximity Read ↗

Type III Interferons: Emerging Roles in AutoimmunitySemantic proximity Read ↗

Type I Interferons in Autoimmunity: Implications in Clinical Phenotypes and Treatment Response.Semantic proximity Read ↗

Role for interferon regulatory factors in autoimmunity.Semantic proximity Read ↗

The Role of Cutaneous Type I IFNs in Autoimmune and Autoinflammatory DiseasesSemantic proximity Read ↗

CD8+ T Cell–Mediated Skin Disease in Mice Lacking IRF-2, the Transcriptional Attenuator of Interferon-α/β SignalingSemantic proximity Read ↗

Type I interferons in health and disease: molecular aspects and clinical implicationsSemantic proximity Read ↗

Autoimmunity: homeostasis of innate immunity gone awry.Semantic proximity Read ↗

Genetic control directed toward spontaneous IFN-alpha/IFN-beta responses and downstream IFN-gamma expression influences the pathogenesis of a murine psoriasis-like skin disease.Semantic proximity Read ↗

Type I interferon-mediated monogenic autoinflammation: The type I interferonopathies, a conceptual overview.Semantic proximity Read ↗

Type I Interferon and the Spectrum of Susceptibility to Viral Infection and Autoimmune Disease: A Shared Genomic Signature.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.