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Article

Generation and Characterization of a Zebrafish IL-2Rγc SCID Model.

International journal of molecular sciences - 21 Feb 2022

Sertori Robert, Jones Realla, Basheer Faiza, Rivera Leni, Dawson Samantha, Loke Stella, Heidary Somayyeh, Dhillon Amardeep, Liongue Clifford, Ward Alister C

Abstract excerpt

The IL-2 family of cytokines act via receptor complexes that share the interleukin-2 receptor gamma common (IL-2Rγc) chain to play key roles in lymphopoiesis. Inactivating IL-2Rγc mutations results in severe combined immunodeficiency (SCID) in humans and other species. This study sought to generate an equivalent zebrafish SCID model. The zebrafish il2rga gene was targeted for genome editing using TALENs and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35216498
DOI: 10.3390/ijms23042385
PMCID: PMC8875600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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