Article
Functional role of type I and type II interferons in antiviral defense.
Science (New York, N.Y.) - 24 Jun 1994
Müller U, Steinhoff U, Reis L F, Hemmi S, Pavlovic J, Zinkernagel R M, Aguet M
Abstract excerpt
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, des...
Topics
- Alphavirus Infections
- Animals
- Antibodies, Viral
- Disease Susceptibility
- Immunity, Innate
- Interferon Type I
- Interferon-gamma
- Lymphocytic Choriomeningitis
- Membrane Proteins
- Mice
- Mutation
- Receptor, Interferon alpha-beta
- Receptors, Interferon
- Rhabdoviridae Infections
- Semliki forest virus
- Signal Transduction
- T-Lymphocytes
- Vesicular stomatitis Indiana virus