Immune response in mice that lack the interferon-gamma receptor.

doi:10.1126/science.8456301

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Article

Immune response in mice that lack the interferon-gamma receptor.

Science (New York, N.Y.) - 19 Mar 1993

Huang S, Hendriks W, Althage A, Hemmi S, Bluethmann H, Kamijo R, Vilcek J, Zinkernagel R M, Aguet M

Abstract excerpt

Interferon-gamma (IFN-gamma) exerts pleiotropic effects, including antiviral activity, stimulation of macrophages and natural killer cells, and increased expression of major histocompatibility complex antigens. Mice without the IFN-gamma receptor had no overt anomalies, and their immune system ap...

Topics

Animals
Antibodies, Viral
Immunity
Immunoglobulin G
Interferon-gamma
Listeriosis
Lymphocyte Subsets
Mice
Mice, Inbred C57BL
Mice, Transgenic
Mutation
Receptors, Interferon
T-Lymphocytes, Cytotoxic
T-Lymphocytes, Helper-Inducer
Vaccinia
Virus Diseases
Virus Replication

Source

Open in PubMed

Identifiers

PMID: 8456301
DOI: 10.1126/science.8456301

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8456301-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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