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Article

Multiple defects of immune cell function in mice with disrupted interferon-gamma genes.

Science (New York, N.Y.) - 19 Mar 1993

Dalton D K, Pitts-Meek S, Keshav S, Figari I S, Bradley A, Stewart T A

Abstract excerpt

Interferon-gamma (IFN-gamma) is a pleiotrophic cytokine with immunomodulatory effects on a variety of immune cells. Mice with a targeted disruption of the IFN-gamma gene were generated. These mice developed normally and were healthy in the absence of pathogens. However, mice deficient in IFN-gamma had impaired production of macrophage antimicrobial products and reduced expression of macrophage major...

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Identifiers

PMID: 8456300
DOI: 10.1126/science.8456300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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