Article
Multiple defects of immune cell function in mice with disrupted interferon-gamma genes.
Science (New York, N.Y.) - 19 Mar 1993
Dalton D K, Pitts-Meek S, Keshav S, Figari I S, Bradley A, Stewart T A
Abstract excerpt
Interferon-gamma (IFN-gamma) is a pleiotrophic cytokine with immunomodulatory effects on a variety of immune cells. Mice with a targeted disruption of the IFN-gamma gene were generated. These mice developed normally and were healthy in the absence of pathogens. However, mice deficient in IFN-gamm...
Topics
- Animals
- Cell Division
- Cytotoxicity, Immunologic
- Histocompatibility Antigens Class II
- Immunity
- Interferon-gamma
- Isoantigens
- Killer Cells, Natural
- Lymphocyte Culture Test, Mixed
- Macrophages
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutation
- Mycobacterium bovis
- Nitric Oxide
- Spleen
- T-Lymphocytes