Reduced joining of DNA double strand breaks with an abnormal mutation spectrum in rodent mutants of DNA-PKcs and Ku80.

doi:10.1080/095530098142004

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Article

Reduced joining of DNA double strand breaks with an abnormal mutation spectrum in rodent mutants of DNA-PKcs and Ku80.

International journal of radiation biology - 1 May 1998

Tzung T Y, Rünger T M

Abstract excerpt

PURPOSE: To characterize further the contribution of the DNA-PK-dependent dsb repair pathway in mammalian cells. MATERIALS AND METHODS: The efficiency and fidelity of the joining of linear plasmids by DNA-PKcs-defective mouse cells (SCID) and Ku80-defective Chinese hamster ovary cells (xrs-6) was...

Topics

3T3 Cells
Animals
Antigens, Nuclear
CHO Cells
Cricetinae
DNA
DNA Damage
DNA Helicases
DNA Repair
DNA, Bacterial
DNA, Circular
DNA-Activated Protein Kinase
DNA-Binding Proteins
Ku Autoantigen
Mice
Mice, SCID
Mutation
Nuclear Proteins

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