A functionally deficient DRD2 variant [Ser311Cys] is not linked to alcoholism and substance abuse.

doi:10.1016/s0741-8329(97)00176-6

Back to search

Article

A functionally deficient DRD2 variant [Ser311Cys] is not linked to alcoholism and substance abuse.

Alcohol (Fayetteville, N.Y.) - 1 Jul 1998

Goldman D, Urbanek M, Guenther D, Robin R, Long J C

Abstract excerpt

Association studies with the DRD2 Taq1A marker have been variable in implicating DRD2 as a "Reward Deficiency Syndrome Gene" for alcoholism and substance abuse. Given that the Taq1A marker is not functionally significant, second-generation studies on the DRD2 receptor to identify functional varia...

Topics

Alcoholism
Amino Acid Sequence
Genetic Linkage
Genetic Variation
Humans
Indians, North American
Receptors, Dopamine D2
Substance-Related Disorders

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.