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Article

A functionally deficient DRD2 variant [Ser311Cys] is not linked to alcoholism and substance abuse.

Alcohol (Fayetteville, N.Y.) - 1 Jul 1998

Goldman D, Urbanek M, Guenther D, Robin R, Long J C

Abstract excerpt

Association studies with the DRD2 Taq1A marker have been variable in implicating DRD2 as a "Reward Deficiency Syndrome Gene" for alcoholism and substance abuse. Given that the Taq1A marker is not functionally significant, second-generation studies on the DRD2 receptor to identify functional variants and evaluate their effect on the phenotype are the logical step towards confirming and extending the DRD2...

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Source

Identifiers

PMID: 9650635
DOI: 10.1016/s0741-8329(97)00176-6

Genes

DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A functionally deficient DRD2 variant [Ser311Cys] is not linked to alcoholism and substance abuse.PMID 9650635Read ↗

Linkage and association of a functional DRD2 variant [Ser311Cys] and DRD2 markers to alcoholism, substance abuse and schizophrenia in Southwestern American Indians.Semantic proximity Read ↗

No association of the structural dopamine D2 receptor (DRD2) variant 311Cys with alcoholism.Semantic proximity Read ↗

Association of structural polymorphism of the dopamine D2 receptor gene and alcoholism.Semantic proximity Read ↗

A structural polymorphism of human dopamine D2 receptor, D2(Ser311-->Cys).Semantic proximity Read ↗

Functional variant in the DRD2 receptor promoter region and subtypes of alcoholism.Semantic proximity Read ↗

Dopamine DRD2/Cys311 is not associated with chronic schizophrenia.Semantic proximity Read ↗

No major role for the dopamine D2 receptor Ser-->Cys311 mutation in schizophrenia.Semantic proximity Read ↗

Dopamine D2 receptor gene Ser311Cys variant and schizophrenia: association study and meta‐analysisSemantic proximity Read ↗

Advanced research on dopamine signaling to develop drugs for the treatment of mental disorders: Ser311Cys polymorphisms of the dopamine D2-receptor gene and schizophrenia.Semantic proximity Read ↗

The DRD2 gene in psychiatric and neurological disorders and its phenotypes.Semantic proximity Read ↗

Association study of bipolar disorder using a functional polymorphism (Ser311-->Cys) in the dopamine D2 receptor gene.Semantic proximity Read ↗

No Structural Mutation in the Dopamine D2 Receptor Gene in Alcoholism or SchizophreniaSemantic proximity Read ↗

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