Article
A structural polymorphism of human dopamine D2 receptor, D2(Ser311-->Cys).
Biochemical and biophysical research communications - 15 Nov 1993
Itokawa M, Arinami T, Futamura N, Hamaguchi H, Toru M
Abstract excerpt
No structural change of the dopamine D2 receptor (DRD2) has been reported so far, though the DRD2 gene has been suggested to be one of the candidate genes for mental disorders. Herein we report one missense nucleotide mutation from C to G resulting in a substitution of serine with cystein at the...
Topics
- Alleles
- Base Sequence
- Brain
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- Cysteine
- DNA
- DNA Primers
- Exons
- Genes, Regulator
- Genetic Carrier Screening
- Homozygote
- Humans
- Molecular Sequence Data
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length