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Article

Sumoylation of Sir2 differentially regulates transcriptional silencing in yeast.

Nucleic acids research - 2 Dec 2015

Hannan Abdul, Abraham Neethu Maria, Goyal Siddharth, Jamir Imlitoshi, Priyakumar U Deva, Mishra Krishnaveni

Abstract excerpt

Silent information regulator 2 (Sir2), the founding member of the conserved sirtuin family of NAD(+)-dependent histone deacetylase, regulates several physiological processes including genome stability, gene silencing, metabolism and life span in yeast. Within the nucleus, Sir2 is associated with telomere clusters in the nuclear periphery and rDNA in the nucleolus and regulates gene silencing at these genomic...

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Identifiers

PMID: 26319015
DOI: 10.1093/nar/gkv842
PMCID: PMC4666389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sumoylation of Sir2 differentially regulates transcriptional silencing in yeast.PMID 26319015Read ↗

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The Sir2 Family of Protein DeacetylasesSemantic proximity Read ↗

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Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity.Semantic proximity Read ↗

Schizosaccharomyces pombe mst2+ encodes a MYST family histone acetyltransferase that negatively regulates telomere silencing.Semantic proximity Read ↗

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