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Article

Spontaneous rDNA copy number variation modulates Sir2 levels and epigenetic gene silencing.

Genes & development - 15 May 2005

Michel Agnès H, Kornmann Benoît, Dubrana Karine, Shore David

Abstract excerpt

We show that in budding yeast large rDNA deletions arise frequently and cause an increase in telomeric and mating-type gene silencing proportional to repeat loss. Paradoxically, this increase in silencing is correlated with a highly specific down-regulation of SIR2, which encodes a deacetylase enzyme required for silencing. These apparently conflicting observations suggest that a large nucleolar pool of Sir2 is...

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Source

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Identifiers

PMID: 15905408
DOI: 10.1101/gad.340205
PMCID: PMC1132006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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