Article
Circulating anti-p53 antibodies in esophageal cancer patients are found predominantly in individuals with p53 core domain mutations in their tumors.
Cancer research - 1 Nov 1996
von Brevern M C, Hollstein M C, Cawley H M, De Benedetti V M, Bennett W P, Liang L, He A G, Zhu S M, Tursz T, Janin N, Trivers G E
Abstract excerpt
Serum antibodies reacting with the tumor suppressor protein p53 have been detected previously in cancer patients with a variety of neoplasms. Two initial (although insufficient) prerequisites for a B-cell response to occur have been proposed: p53 protein accumulation in the tumor or a mutant p53...
Topics
- Adult
- Aged
- Aged, 80 and over
- Antibodies
- Esophageal Neoplasms
- Female
- Genes, p53
- Humans
- Male
- Middle Aged
- Mutation
- Tumor Suppressor Protein p53