Article
Circulating anti-p53 antibodies in esophageal cancer patients are found predominantly in individuals with p53 core domain mutations in their tumors.
Cancer research - 1 Nov 1996
von Brevern M C, Hollstein M C, Cawley H M, De Benedetti V M, Bennett W P, Liang L, He A G, Zhu S M, Tursz T, Janin N, Trivers G E
Abstract excerpt
Serum antibodies reacting with the tumor suppressor protein p53 have been detected previously in cancer patients with a variety of neoplasms. Two initial (although insufficient) prerequisites for a B-cell response to occur have been proposed: p53 protein accumulation in the tumor or a mutant p53 gene, or both. We have examined 65 esophageal cancer cases (42 from Guangzhou and Shenyang, People's Republic of China,...
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