Article
Evaluation of p53 protein expression in Barrett's esophagus by two-parameter flow cytometry.
Gastroenterology - 1 Apr 1992
Ramel S, Reid B J, Sanchez C A, Blount P L, Levine D S, Neshat K, Haggitt R C, Dean P J, Thor K, Rabinovitch P S
Abstract excerpt
Barrett's esophagus is a condition in which the normal stratified squamous epithelium is replaced by metaplastic columnar epithelium that predisposes to the development of esophageal adenocarcinoma. Neoplastic progression in Barrett's esophagus occurs by a multistep process associated with genomic instability and the development of aneuploid cell populations. p53 protein overexpression and allelic deletions on...
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