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Article

Reduced transduction efficiency of adenoviral vectors expressing human p53 gene by repeated transduction into glioma cells in vitro.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2002

Yamamoto Shinji, Yoshida Yoko, Aoyagi Masaru, Ohno Kikuo, Hirakawa Kimiyoshi, Hamada Hirofumi

Abstract excerpt

PURPOSE: Recombinant adenoviral vectors are widely used in clinical and experimental studies to treat malignant tumors. Recently, host immune responses have been proposed as a major limitation in using adenoviral vectors for repeated gene delivery. We demonstrate another limitation unrelated to host immunity. EXPERIMENTAL DESIGN: We repeatedly transduced an adenoviral vector expressing the human p53 gene...

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Share to Adenoviridae
Share to Cell Adhesion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Transfer Techniques

Share to Genetic Vectors

Share to Glioma

Share to Integrins

Share to Receptors, Virus

Share to Transduction, Genetic

Source

Identifiers

PMID: 11895926

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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