Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Potential of adenoviral p53 gene therapy and irradiation for the treatment of malignant gliomas.

International journal of oncology - 1 Nov 2001

Kim I A, Yang Y J, Yoon S C, Choi I B, Kay C S, Kwon H C, Kim C M, Joe Y A, Kang J K, Hong Y K

Abstract excerpt

We investigated the combined effects of p53 gene transfer and irradiation and its still unclear interaction mechanism in human gliomas. Four human glioma cell lines expressing mutant type p53 (U373 and A172) and wild-type p53 (D54MG and EFC-2) were transfected by adenoviral vectors bearing p53 gene at 50 multiplicity of infection. Two days after transfection, cells were irradiated (3, 6, and 9 Gy). The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Cycle

Share to Combined Modality Therapy

Share to Dose-Response Relationship, Radiation

Share to Genetic Therapy

Share to Genetic Vectors

Share to Glioma

Source

Identifiers

PMID: 11605007
DOI: 10.3892/ijo.19.5.1041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Potential of adenoviral p53 gene therapy and irradiation for the treatment of malignant gliomas.PMID 11605007Read ↗

Enhancement of radiosensitivity of wild-type p53 human glioma cells by adenovirus-mediated delivery of the p53 gene.Semantic proximity Read ↗

Cell cycle checkpoint and apoptosis induction in glioblastoma cells and fibroblasts irradiated with carbon beam.Semantic proximity Read ↗

Adenovirus-mediated transfer of p53 augments hyperthermia-induced apoptosis in U251 glioma cells.Semantic proximity Read ↗

Adenovirus-mediatedp53 gene transfer suppresses growth of human glioblastoma cellsin vitro andin vivoSemantic proximity Read ↗

Effects of ionizing radiation on the viability and proliferative behavior of the human glioblastoma T98G cell lineSemantic proximity Read ↗

Effects of adenoviral wild-type p53 gene transfer in p53-mutated lymphoma cells.Semantic proximity Read ↗

p53-dependent G2 arrest associated with a decrease in cyclins A2 and B1 levels in a human carcinoma cell line.Semantic proximity Read ↗

Use of wild-type p53 to achieve complete treatment sensitization of tumor cells expressing endogenous mutant p53.Semantic proximity Read ↗

Restoration of the G1 checkpoint and the apoptotic pathway mediated by wild-type p53 sensitizes squamous cell carcinoma of the head and neck to radiotherapy.Semantic proximity Read ↗

[Enhancement of HepG2 cell radiosensitivity by mutant IkappaBalpha gene transfection].Semantic proximity Read ↗

Reduced transduction efficiency of adenoviral vectors expressing human p53 gene by repeated transduction into glioma cells in vitro.Semantic proximity Read ↗

p53 and Egr-1 additively suppress transformed growth in HT1080 cells but Egr-1 counteracts p53-dependent apoptosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.