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Article

Therapeutic efficacy of PUMA for malignant glioma cells regardless of p53 status.

Human gene therapy - 1 Jun 2005

Ito Hideaki, Kanzawa Takao, Miyoshi Toru, Hirohata Satoshi, Kyo Satoru, Iwamaru Arifumi, Aoki Hiroshi, Kondo Yasuko, Kondo Seiji

Abstract excerpt

Replacement of the p53 tumor suppressor gene is a rational approach to the management of malignant gliomas because p53 is frequently mutated or inactivated in these cancers. Major weaknesses of this approach are that malignant gliomas are mixtures of cells with wild-type and mutant p53, and that tumor cells exhibiting wildtype p53 are resistant to p53 gene transfer. An effective alternative is needed to overcome...

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Identifiers

PMID: 15960600
DOI: 10.1089/hum.2005.16.685
PMCID: PMC1387050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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