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Article

Adenovirus-mediated transfer of p53 augments hyperthermia-induced apoptosis in U251 glioma cells.

International journal of radiation oncology, biology, physics - 1 Jun 2001

Okamoto K, Shinoura N, Egawa N, Asai A, Kirino T, Shibasaki F, Shitara N

Abstract excerpt

PURPOSE: Hyperthermia kills glioma cells by inducing apoptosis and is thereby an effective therapeutic modality for the treatment of malignant gliomas. However, cells harboring mutated p53 are refractory to hyperthermia-induced apoptosis. In this study, we assessed whether or not adenovirus (Adv)-mediated transduction of p53 overrides this resistant mechanism. METHODS AND MATERIALS: We transduced the p53...

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Share to Adenoviridae
Share to Combined Modality Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Fragmentation

Share to Genes, p53

Share to Genetic Therapy

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Share to Transduction, Genetic

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 11380242
DOI: 10.1016/s0360-3016(01)01474-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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