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Article

Gene Therapy for Malignant Glioma: Current Clinical Status

11 Aug 2005

Abstract excerpt

Glioblastoma is an aggressive brain tumor with a dismal prognosis. Gene therapy may offer a new option for the treatment of these patients. Several gene therapy approaches have shown anti-tumor efficiency in experimental studies, and the first clinical trials for the treatment of malignant glioma were conducted in the 1990s. HSV-tk gene therapy has been the pioneering and most commonly used approach, but...

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PMID: 16095972
DOI: 10.1016/j.ymthe.2005.07.357

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