Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential activation of the Fas/CD95 pathway by Ad-p53 in human gliomas.

International journal of oncology - 1 Feb 2004

Cerrato Julie A, Khan Tahira, Koul Dimpy, Lang Frederick F, Conrad Charles A, Yung W K Alfred, Liu Ta-Jen

Abstract excerpt

Adenoviral p53 gene transfer (Ad-p53) induces apoptosis in glioma cells expressing mutant p53, but fails in cells with wild-type p53. Endogenously, gliomas express varied levels of Fas/CD95, yet constitutively high levels of Fas/CD95 ligand. Because the mechanism behind the differential apoptotic response to Ad-p53 infection remains elusive, we examined how the Fas/CD95 pathway is involved in U87MG (wt-p53), D54...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Brefeldin A
Share to Caspase 8

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caspases

Share to Fas Ligand Protein

Share to fas Receptor

Share to Glioma

Share to Ribonucleases

Source

Identifiers

PMID: 14719118

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential activation of the Fas/CD95 pathway by Ad-p53 in human gliomas.PMID 14719118Read ↗

Introduction of mutant p53 into a wild-type p53-expressing glioma cell line confers sensitivity to Ad-p53-induced apoptosis.Semantic proximity Read ↗

Therapeutic efficacy of PUMA for malignant glioma cells regardless of p53 status.Semantic proximity Read ↗

Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants.Semantic proximity Read ↗

Caspase-9 transduction overrides the resistance mechanism against p53-mediated apoptosis in U-87MG glioma cells.Semantic proximity Read ↗

Adenovirus-mediated transfer of p53 augments hyperthermia-induced apoptosis in U251 glioma cells.Semantic proximity Read ↗

Characterization of p53 and p21 functional interactions in glioma cells en route to apoptosis.Semantic proximity Read ↗

Restoration of p53 function for selective Fas-mediated apoptosis in human and rat glioma cells in vitro and in vivo by a p53 COOH-terminal peptide.Semantic proximity Read ↗

Chimeric tumor suppressor 1, a p53-derived chimeric tumor suppressor gene, kills p53 mutant and p53 wild-type glioma cells in synergy with irradiation and CD95 ligand.Semantic proximity Read ↗

Enhancement of radiosensitivity of wild-type p53 human glioma cells by adenovirus-mediated delivery of the p53 gene.Semantic proximity Read ↗

A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis.Semantic proximity Read ↗

p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer DrugsSemantic proximity Read ↗

Differential involvement of the CD95 (Fas/APO-1) receptor/ligand system on apoptosis induced by the wild-type p53 gene transfer in human cancer cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.