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Article

Tp53-gene transfer induces hypersensitivity to low doses of X-rays in glioblastoma cells: a strategy to convert a radio-resistant phenotype into a radiosensitive one.

Cancer letters - 8 Jan 2006

D'Avenia Paola, Porrello Alessandro, Berardo Marco, Angelo Marco D', Soddu Silvia, Arcangeli Giorgio, Sacchi Ada, D'Orazi Gabriella

Abstract excerpt

Tp53 is frequently mutated or inactivated in glioblastomas. Due to the impairment of p53 activity, glioblastomas show a high degree of radioresistance. In an attempt to convert the radioresistant phenotype to a more radiosensitive one, we evaluated the efficacy of the combination of Adp53 gene transfer and X-ray irradiation. The combination of Adp53, at low multiplicity in order to mimic the low in vivo...

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Identifiers

PMID: 16356835
DOI: 10.1016/j.canlet.2005.01.033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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