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Article

Attenuation of a reactivated cardiovirulent coxsackievirus B3: The 5'-nontranslated region does not contain major attenuation determinants.

Journal of medical virology - 1 Oct 1993

Zhang H Y, Yousef G E, Cunningham L, Blake N W, OuYang X, Bayston T A, Kandolf R, Archard L C

Abstract excerpt

To investigate the molecular basis of pathogenicity of Coxsackieviruses, a virus was reactivated by transfection from a full-length cDNA clone derived from cardiovirulent Coxsackievirus B3 (CVB3). The reactivated virus, rCVB3, was passaged serially in human dermatofibroblasts (HDF). No cytopathic effect was observed up to 12 days after inoculation with rCVB3 or early-passage virus, although disintegration of the...

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PMID: 8283174
DOI: 10.1002/jmv.1890410208

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Attenuation of a reactivated cardiovirulent coxsackievirus B3: The 5'-nontranslated region does not contain major attenuation determinants.PMID 8283174Read ↗

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