Article
Changes of mutant-type p53 expression in squamous cell carcinoma of the head and neck during radiation therapy and its clinical significance: comparison of an immunohistochemical method and PCR-SSCP assay.
Oncology reports - 1 Jan 2000
Ogawa Y, Nishioka A, Hamada N, Terashima M, Inomata T, Yoshida S, Seguchi H, Kishimoto S
Abstract excerpt
P53 has been reported to be one of tumor suppressor genes that play a major role in signal transduction following many kinds of stresses, including ionizing radiation. Changes in p53 expression during radiation therapy in tumor tissues have not yet been reported. We determined whether radiotherap...
Topics
- Adult
- Aged
- Carcinoma, Squamous Cell
- Exons
- Female
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Head and Neck Neoplasms
- Humans
- Male
- Middle Aged
- Mutation
- Neoplasm Staging
- Polymerase Chain Reaction