Mutations in the p53 gene in radiation-sensitive and -resistant human squamous carcinoma cells.

Article

Mutations in the p53 gene in radiation-sensitive and -resistant human squamous carcinoma cells.

Cancer research - 15 Nov 1992

Jung M, Notario V, Dritschilo A

Abstract excerpt

Five of six human squamous cell carcinoma (SCC) cell lines characterized as radiation sensitive (SQ-38, SCC-9, SQ-9G) or radiation resistant (SQ-20B, SCC-35, JSQ-3) exhibited alterations of the p53 gene. The point mutations and a deletion were detected by using single-stranded conformational poly...

Topics

Carcinoma, Squamous Cell
DNA, Neoplasm
Exons
Genes, p53
Head and Neck Neoplasms
Humans
Immunohistochemistry
Mutation
Phenotype
Radiation Tolerance

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