Article
Mutational analysis of Bax and Bcl-2 in childhood acute lymphoblastic leukaemia.
International journal of cancer - 19 Jun 1998
Salomons G S, Buitenhuis C K, Martínez Muñoz C, Verwijs-Jassen M, Behrendt H, Zsiros J, Smets L A
Abstract excerpt
In childhood acute lymphoblastic leukaemia there are large interpatient variations in levels of the apoptosis-regulating proteins Bax and Bcl-2, but the molecular basis for this variation is unknown. Point-mutations in bax have been reported in cell lines derived from haematological malignancies....
Topics
- Adolescent
- Base Sequence
- Bone Marrow
- Child
- Child, Preschool
- DNA Mutational Analysis
- Genes, bcl-2
- Humans
- Infant
- Infant, Newborn
- Molecular Sequence Data
- Mutation
- Open Reading Frames
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2
- bcl-2-Associated X Protein