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Article

Mutational analysis of Bax and Bcl-2 in childhood acute lymphoblastic leukaemia.

International journal of cancer - 19 Jun 1998

Salomons G S, Buitenhuis C K, Martínez Muñoz C, Verwijs-Jassen M, Behrendt H, Zsiros J, Smets L A

Abstract excerpt

In childhood acute lymphoblastic leukaemia there are large interpatient variations in levels of the apoptosis-regulating proteins Bax and Bcl-2, but the molecular basis for this variation is unknown. Point-mutations in bax have been reported in cell lines derived from haematological malignancies. Frameshift mutations, which result in reduced Bax levels, have also been found in colon cancer of the microsatellite...

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Identifiers

PMID: 9645350
DOI: 10.1002/(sici)1097-0215(19980619)79:3<273::aid-ijc11>3.0.co;2-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutational analysis of Bax and Bcl-2 in childhood acute lymphoblastic leukaemia.PMID 9645350Read ↗

Hematopoietic malignancies demonstrate loss-of-function mutations of BAX.Semantic proximity Read ↗

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Increased BAX Expression Is Associated With an Increased Risk of Relapse in Childhood Acute Lymphocytic LeukemiaSemantic proximity Read ↗

Mutation analysis of CD95 (APO-1/Fas) in childhood B-lineage acute lymphoblastic leukaemia.Semantic proximity Read ↗

Expression and Regulation of Bcl-2, Bcl-xl, and Bax Correlate With p53 Status and Sensitivity to Apoptosis in Childhood Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

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Sensitivity to Fas-mediated apoptosis in pediatric acute lymphoblastic leukemia is associated with a mutant p53 phenotype and absence of Bcl-2 expression.Semantic proximity Read ↗

Loss of BCL-2 in the progression of oral cancer is not attributable to mutations.Semantic proximity Read ↗

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