Article
Infrequent bax gene mutations in B-cell lymphomas.
The Journal of pathology - 1 Dec 1998
Peng H, Aiello A, Packham G, Isaacson P G, Pan L
Abstract excerpt
Mutation of the bax gene has been reported previously in lymphoid cell lines. In vitro experiments have shown that alterations in promoter and coding sequences of the gene abolish its apoptosis initiation function, which is considered crucial for tumour development. To assess bax gene mutations in lymphomagenesis, polymerase chain reaction-based single strand conformation polymorphism analysis (PCR-SSCP) and...
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